Three short stories by JD Salinger, which the reclusive author did not want published, have been leaked online.
The Ocean Full Of Bowling Balls, Paula and Birthday had previously only been available to read at two American university libraries. The first title, in particular, is of particular importance, as it inspired elements of The Catcher In The Rye. A scanned copy of the stories was uploaded to a file-sharing website this week, and rapidly spread online. The collection, titled Three Stories, features a plain black cover, and also contains a letter from Salinger to his publisher Little, Brown and Company, discussing proof copies of his works. David Ulin, a book critic with the Los Angeles Times, said that at least two of the stories in the collection were “the real deal”. “I’ve never read The Ocean Full of Bowling Balls,” he wrote. “It’s part of a collection of Salinger material at the Princeton University Library and available only to scholars who are supervised as they read. “I have read the other two stories, however, at the University of Texas’ Ransom Center, and the versions of them in Three Stories are the real deal.” “The Ransom Center is relatively free with its manuscripts; visitors can even have photocopies made, although they are prohibited from circulating the work.
Researchers find a missing component in effort to create primitive, synthetic cells
A team of Massachusetts General Hospital (MGH) investigators working to create “protocells” – primitive synthetic cells consisting of a nucleic acid strand encased within a membrane-bound compartment – have accomplished an important step towards their goal. In the November 28 issue of Science, the investigators describe a solution to what could have been a critical problem – the potential incompatibility between a chemical requirement of RNA copying and the stability of the protocell membrane. “For the first time, we’ve been able to do nonenzymatic RNA copying inside fatty acid vesicles,” says Jack Szostak, PhD, of the MGH Department of Molecular Biology and the Center for Computational and Integrative Biology. “We’ve found a solution to a longstanding problem in the origin of cellular life: RNA copying chemistry requires the presence of the magnesium ion Mg2 , but high Mg2 levels can break down the simple, fatty acid membranes that probably surrounded the first living cells.” (via Researchers find a missing component in effort to create primitive, synthetic cells)
See on Scoop.it - The future of medicine and health
Engineer immune cells to recognise tumour cells they would otherwise overlook and they call a halt to cancers we thought were incurable
"THE results are holding up very nicely." Cancer researcher Michel Sadelain is admirably understated about the success of a treatment developed in his lab at the Memorial Sloan-Kettering Cancer Center in New York.
In March, he announced that five people with a type of blood cancer called acute lymphoblastic leukaemia (ALL) were in remission following treatment with genetically engineered immune cells from their own blood. One person’s tumours disappeared in just eight days.
Sadelain has now told New Scientist that a further 11 people have been treated, almost all of them with the same outcome. Several trials for other cancers are also showing promise.
What has changed is that researchers are finding ways to train the body’s own immune system to kill cancer cells. Until now, the most common methods of attacking cancer use drugs or radiation, which have major side effects and are blunt instruments to say the least.
The latest techniques involve genetically engineering immune T-cells to target and kill cancer cells, while leaving healthy cells relatively unscathed.
See on newscientist.com