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Neurons in the brain switch identity and re-route fibres
New findings could one day lead to gene therapies for stroke and spinal cord injuries
These drawings by Santiago Ramón y Cajal show the cellular structure of three different areas of the human cerebral cortex. The cortex is the seat of higher mental functions such as language and decision-making, and contains dozens of distinct, specialised areas. As Cajal’s drawings show, it has a characteristic layered structure, which differs somewhat from one area to the next, so that the layers vary in thickness according to the number of cells they contain. Cells throughout the cortex are arranged in a highly ordered manner. Those in layers 2 and 3, for example, send fibres to the other side of the brain, whereas those in layers 5 and 6 send theirs straight downwards. This organization is under genetic control and, once established, was thought to be fixed. Now, though, researchers at Harvard University report that fully matured neurons in the intact brain can be made to switch identity and re-route their fibres to acquire the characteristics of cells in other layers. (via Neurons in the brain switch identity and re-route fibres | Mo Costandi | Science | guardian.co.uk)

Neurons in the brain switch identity and re-route fibres

New findings could one day lead to gene therapies for stroke and spinal cord injuries

These drawings by Santiago Ramón y Cajal show the cellular structure of three different areas of the human cerebral cortex. The cortex is the seat of higher mental functions such as language and decision-making, and contains dozens of distinct, specialised areas. As Cajal’s drawings show, it has a characteristic layered structure, which differs somewhat from one area to the next, so that the layers vary in thickness according to the number of cells they contain. Cells throughout the cortex are arranged in a highly ordered manner. Those in layers 2 and 3, for example, send fibres to the other side of the brain, whereas those in layers 5 and 6 send theirs straight downwards. This organization is under genetic control and, once established, was thought to be fixed. Now, though, researchers at Harvard University report that fully matured neurons in the intact brain can be made to switch identity and re-route their fibres to acquire the characteristics of cells in other layers. (via Neurons in the brain switch identity and re-route fibres | Mo Costandi | Science | guardian.co.uk)